Richard J Auchus Selected Research

Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)

1/2017	Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic.
4/2016	Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.
9/2014	A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone.
2/2014	Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency.
2/2012	Human steroid biosynthesis for the oncologist.
11/2010	Combined 17α-hydroxylase/17,20-lyase deficiency due to p.R96W mutation in the CYP17 gene in a Brazilian patient.
2/2008	Novel mutation in cytochrome P450c17 causes complete combined 17alpha-hydroxylase/17,20-lyase deficiency.
1/2004	Two prevalent CYP17 mutations and genotype-phenotype correlations in 24 Brazilian patients with 17-hydroxylase deficiency.
12/2003	CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.
11/2002	Towards a unifying mechanism for CYP17 mutations that cause isolated 17,20-lyase deficiency.

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Richard J Auchus Research Topics

Disease

29	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 08/2010
25	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 12/2022 - 01/2008
25	Hypertension (High Blood Pressure) 01/2021 - 03/2003
22	Neoplasms (Cancer) 01/2022 - 03/2009
14	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 01/2022 - 08/2014
13	Hyperaldosteronism (Conn Syndrome) 06/2022 - 03/2003
12	Cushing Syndrome 06/2022 - 12/2007
10	Adenoma (Adenomas) 01/2021 - 03/2003
8	Virilism (Virilization) 01/2020 - 05/2006
7	Insulin Resistance 01/2022 - 04/2009
7	Hypokalemia 01/2021 - 01/2004
5	Isolated 17,20-Lyase Deficiency 01/2017 - 11/2002
5	Asthma (Bronchial Asthma) 05/2016 - 01/2011
4	Adrenal Insufficiency (Adrenal Gland Hypofunction) 06/2022 - 02/2008
4	Paraganglioma (Paragangliomas) 02/2020 - 03/2009
4	Pheochromocytoma 02/2020 - 03/2009
3	Adrenal Rest Tumor 01/2022 - 06/2015
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 08/2012
3	Lipodystrophy 01/2022 - 08/2003
3	Essential Hypertension 02/2020 - 02/2008
3	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2020 - 01/2011
3	Hirsutism 01/2017 - 01/2011
3	Sexual Infantilism 01/2017 - 02/2008
3	Familial Hyperaldosteronism 01/2016 - 08/2012
3	Disorders of Sex Development (Intersexuality) 10/2012 - 01/2004
2	Cardiomyopathies (Cardiomyopathy) 01/2022 - 08/2017
2	Hyperinsulinism (Hyperinsulinemia) 01/2021 - 01/2017
2	Hyperglycemia 01/2021 - 12/2014
2	Obesity 11/2020 - 08/2014
2	Hyperkalemia 10/2019 - 03/2011
2	Addison Disease (Addison's Disease) 01/2019 - 07/2013
2	Infections 01/2018 - 01/2014
2	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 11/2017 - 08/2003
2	Body Weight (Weight, Body) 11/2017 - 02/2007
2	Glucocorticoid-Remediable Aldosteronism 06/2017 - 04/2015
2	Antley-Bixler Syndrome Phenotype 01/2016 - 12/2007
2	Breast Neoplasms (Breast Cancer) 01/2016 - 02/2012
2	Weight Loss (Weight Reduction) 12/2015 - 02/2007
2	Adrenal Gland Neoplasms (Adrenal Cancer) 08/2015 - 05/2013
2	Inborn Genetic Diseases (Disease, Hereditary) 06/2015 - 03/2009
2	Amenorrhea 02/2014 - 02/2008
2	Infertility (Sterility) 07/2013 - 06/2010

Drug/Important Bio-Agent (IBA)

44	AndrogensIBA 01/2022 - 01/2007
29	SteroidsIBA 01/2022 - 01/2004
26	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2022 - 11/2005
17	AldosteroneIBA 06/2022 - 03/2003
16	EnzymesIBA 01/2021 - 11/2002
14	Hormones (Hormone)IBA 01/2022 - 11/2005
14	Testosterone (Sustanon)FDA Link 01/2022 - 05/2006
13	GlucocorticoidsIBA 06/2022 - 06/2010
10	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 01/2017 - 11/2002
9	abirateroneIBA 01/2018 - 02/2012
8	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 12/2010
8	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 01/2008
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
7	Biomarkers (Surrogate Marker)IBA 02/2021 - 01/2011
7	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2021 - 11/2005
7	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 01/2019 - 07/2013
6	Pharmaceutical PreparationsIBA 01/2020 - 04/2009
6	Mixed Function Oxygenases (Monooxygenases)IBA 11/2017 - 11/2010
6	Abiraterone AcetateIBA 01/2017 - 02/2012
5	Androstenedione (4 Androstene 3,17 dione)IBA 01/2022 - 09/2008
5	Dehydroepiandrosterone (DHEA)IBA 01/2021 - 08/2010
4	SaltsIBA 01/2021 - 03/2006
4	Estrogens (Estrogen)FDA Link 01/2019 - 01/2007
4	Glucose (Dextrose)FDA LinkGeneric 11/2018 - 10/2015
4	MineralocorticoidsIBA 01/2018 - 03/2003
4	CytochromesIBA 01/2017 - 02/2014
3	Cosyntropin (Cortrosyn)FDA LinkGeneric 07/2020 - 06/2014
3	ReninIBA 10/2019 - 03/2003
3	PotassiumIBA 10/2019 - 01/2004
3	LigandsIBA 01/2019 - 06/2009
3	Mineralocorticoid Receptor AntagonistsIBA 01/2019 - 08/2012
3	Messenger RNA (mRNA)IBA 01/2018 - 02/2011
3	Aromatase (CYP19)IBA 01/2017 - 03/2007
3	ProdrugsIBA 01/2017 - 08/2014
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2016 - 02/2012
3	Dexamethasone (Maxidex)FDA LinkGeneric 12/2014 - 02/2012
3	Prednisone (Sone)FDA LinkGeneric 12/2014 - 02/2012
3	Acetates (Acetic Acid Esters)FDA Link 08/2014 - 11/2011
3	Dihydrotestosterone (Androstanolone)IBA 08/2011 - 05/2006
2	Insulin (Novolin)FDA Link 01/2022 - 11/2017
2	17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)IBA 02/2021 - 06/2015
2	Antihypertensive Agents (Antihypertensives)IBA 01/2021 - 01/2019
2	Sulfates (Sulfates, Inorganic)IBA 01/2021 - 02/2011
2	Mifepristone (RU 486)FDA Link 11/2018 - 01/2016
2	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 06/2017 - 11/2005
2	Epithelial Sodium ChannelsIBA 06/2017 - 03/2006
2	Cytochromes b5 (Cytochrome b5)IBA 04/2016 - 11/2002
2	Corticotropin-Releasing HormoneIBA 03/2016 - 07/2014
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2015 - 01/2011
2	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2014 - 09/2013
2	A 17 (A-17)IBA 11/2014 - 02/2012
2	Succinate Dehydrogenase (Fumarate Reductase)IBA 08/2014 - 03/2009
2	CatecholaminesIBA 06/2014 - 03/2009
2	CalciumIBA 12/2013 - 01/2011

Therapy/Procedure

21	Castration 04/2020 - 08/2010
17	Therapeutics 01/2020 - 02/2007
5	Drug Therapy (Chemotherapy) 11/2021 - 04/2009
3	Adrenalectomy 01/2021 - 12/2007